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guinea pig igg anti trpv1  (Neuromics)


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    Neuromics guinea pig igg anti trpv1
    ( A ) Overview of the targeting strategy for the construction of Cpne6 −/− knockout mice. ( B ) Genotyping results showing Cpne6 +/− , Cpne6 − /− and Cpne6 +/+ gene products. ( C ) Representative western blot analysis for Copine-6 expression in the DRG of Cpne6 +/+ and Cpne6 −/− mice. ( D ) Schematic representation of local DRG-rescue by injection of the AAV9-hSyn-Copine-6-EGFP virions into the DRG of Cpne6 −/− mice. ( E ) Confocal micrographs of Copine-6 immunofluorescence (red) and EGFP fluorescence (green) from the DRGs of Cpne6 −/− mice DRG-injected with either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions (1 × 10 13 viral genomes/mL; 2 μL). Scale bars are 100 μm. ( F – I ) Results of the behavioral tests performed on of Cpne6 +/+ and Cpne6 −/− mice DRG injected with either AAV9-hSyn-mCopine-6-EGFP virions or AAV9-hSyn-EGFP control virions. Tests are as follows: von Frey ( F ), Hargreaves ( G ), hot plate ( H ) and dry ice ( I ). n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. *Indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group. G, *** P = 0.0007; #### P < 0.0001. H, 50 °C, ** P = 0.0062, ## P = 0.0021; 52 °C, * P = 0.0292, # P = 0.0164; 55 °C, ** P = 0.006, # P = 0.0232 (one-way ANOVA followed by Bonferroni multiple comparisons test). ( J , K ) On the 35 th day after viral injection of either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions mice were injected with 25 μL of CFA into the plantar surface of right hindpaw and Hargreaves ( J ) or von Frey ( K ) tests were performed at time intervals indicated; n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. * indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group at time points indicated. J, 0 d, ** P = 0.0029, ### P = 0.0001; 1 d, * P = 0.0372, ## P = 0.0029 ; 3 d, * P = 0.0252, # P = 0.0113; 5 d, ** P = 0.009, ## P = 0.0045 . Two-way ANOVA with Bonferroni multiple comparisons test. .
    Guinea Pig Igg Anti Trpv1, supplied by Neuromics, used in various techniques. Bioz Stars score: 93/100, based on 79 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/guinea+pig+anti+trpv1/VR1+C-terminus+(TRPV1)/pmc12317139-25-0-7
    Average 93 stars, based on 79 article reviews
    guinea pig igg anti trpv1 - by Bioz Stars, 2026-09
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    Images

    1) Product Images from "Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat"

    Article Title: Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat

    Journal: The EMBO Journal

    doi: 10.1038/s44318-025-00487-0

    ( A ) Overview of the targeting strategy for the construction of Cpne6 −/− knockout mice. ( B ) Genotyping results showing Cpne6 +/− , Cpne6 − /− and Cpne6 +/+ gene products. ( C ) Representative western blot analysis for Copine-6 expression in the DRG of Cpne6 +/+ and Cpne6 −/− mice. ( D ) Schematic representation of local DRG-rescue by injection of the AAV9-hSyn-Copine-6-EGFP virions into the DRG of Cpne6 −/− mice. ( E ) Confocal micrographs of Copine-6 immunofluorescence (red) and EGFP fluorescence (green) from the DRGs of Cpne6 −/− mice DRG-injected with either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions (1 × 10 13 viral genomes/mL; 2 μL). Scale bars are 100 μm. ( F – I ) Results of the behavioral tests performed on of Cpne6 +/+ and Cpne6 −/− mice DRG injected with either AAV9-hSyn-mCopine-6-EGFP virions or AAV9-hSyn-EGFP control virions. Tests are as follows: von Frey ( F ), Hargreaves ( G ), hot plate ( H ) and dry ice ( I ). n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. *Indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group. G, *** P = 0.0007; #### P < 0.0001. H, 50 °C, ** P = 0.0062, ## P = 0.0021; 52 °C, * P = 0.0292, # P = 0.0164; 55 °C, ** P = 0.006, # P = 0.0232 (one-way ANOVA followed by Bonferroni multiple comparisons test). ( J , K ) On the 35 th day after viral injection of either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions mice were injected with 25 μL of CFA into the plantar surface of right hindpaw and Hargreaves ( J ) or von Frey ( K ) tests were performed at time intervals indicated; n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. * indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group at time points indicated. J, 0 d, ** P = 0.0029, ### P = 0.0001; 1 d, * P = 0.0372, ## P = 0.0029 ; 3 d, * P = 0.0252, # P = 0.0113; 5 d, ** P = 0.009, ## P = 0.0045 . Two-way ANOVA with Bonferroni multiple comparisons test. .
    Figure Legend Snippet: ( A ) Overview of the targeting strategy for the construction of Cpne6 −/− knockout mice. ( B ) Genotyping results showing Cpne6 +/− , Cpne6 − /− and Cpne6 +/+ gene products. ( C ) Representative western blot analysis for Copine-6 expression in the DRG of Cpne6 +/+ and Cpne6 −/− mice. ( D ) Schematic representation of local DRG-rescue by injection of the AAV9-hSyn-Copine-6-EGFP virions into the DRG of Cpne6 −/− mice. ( E ) Confocal micrographs of Copine-6 immunofluorescence (red) and EGFP fluorescence (green) from the DRGs of Cpne6 −/− mice DRG-injected with either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions (1 × 10 13 viral genomes/mL; 2 μL). Scale bars are 100 μm. ( F – I ) Results of the behavioral tests performed on of Cpne6 +/+ and Cpne6 −/− mice DRG injected with either AAV9-hSyn-mCopine-6-EGFP virions or AAV9-hSyn-EGFP control virions. Tests are as follows: von Frey ( F ), Hargreaves ( G ), hot plate ( H ) and dry ice ( I ). n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. *Indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group. G, *** P = 0.0007; #### P < 0.0001. H, 50 °C, ** P = 0.0062, ## P = 0.0021; 52 °C, * P = 0.0292, # P = 0.0164; 55 °C, ** P = 0.006, # P = 0.0232 (one-way ANOVA followed by Bonferroni multiple comparisons test). ( J , K ) On the 35 th day after viral injection of either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions mice were injected with 25 μL of CFA into the plantar surface of right hindpaw and Hargreaves ( J ) or von Frey ( K ) tests were performed at time intervals indicated; n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. * indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group at time points indicated. J, 0 d, ** P = 0.0029, ### P = 0.0001; 1 d, * P = 0.0372, ## P = 0.0029 ; 3 d, * P = 0.0252, # P = 0.0113; 5 d, ** P = 0.009, ## P = 0.0045 . Two-way ANOVA with Bonferroni multiple comparisons test. .

    Techniques Used: Knock-Out, Western Blot, Expressing, Injection, Immunofluorescence, Fluorescence, Control

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    Article Title: Development of a 3-dimensional organotypic model with characteristics of peripheral sensory nerves
    Article Snippet: .. The samples were blocked in blocking buffer (PBS containing 0.1% Tween 20 and 3% BSA) for 1 h at room temperature, and then incubated for 24 h at room temperature with the following primary antibodies: mouse anti-NF200 (1:400, Sigma-Aldrich, #N0142, RRID: AB_477257 ), rabbit anti-CGRP (1:200, Sigma-Aldrich, #C8198, RRID: AB_259091 ), Isolectin B4 (Ib4)-FITC conjugate (1:250, Sigma-Aldrich, #L2895), rabbit anti-MBP (1:1000, Abcam, Cambridge, UK, #ab40390, RRID: AB_1141521 ), mouse anti-Caspr, clone K65/35 (1:100, Merck, Darmstadt, Germany, #MABN69, RRID: AB_10806491 ), rabbit anti-Ezrin (1:200, Cell Signaling Technology, Danvers, MA, USA, #3145, RRID: AB_2100309 ), mouse anti-Tubulin β3 (1:500, BioLegend, San Diego, CA, USA, #801201, RRID: AB_2313773 ), rabbit anti-Nav1.8 (1:200, Alomone labs, Jerusalem, Israel, #ASC-016-GP, RRID: AB_2040188 ), guinea pig anti-TRPV1 (1:200, Neuromics, Edina, MN, USA, #GP14100, RRID: AB_1624142 ), rabbit anti-TRPA1 (1:200, Novus Biologicals, Centennial, CO, USA, #NB110-40763, RRID: AB_715124 ), goat anti-TrkA (1:200, R&D systems, Minneapolis, MN, USA, #AF1056, RRID: AB_2283049 ), goat anti-TrkB (1:200, R&D systems, #AF1494, RRID: AB_2155264 ), rabbit anti-Npy2r (1:50, Sigma-Aldrich, #SAB4502029, RRID: AB_10747296 ), rabbit anti-GFAP (1:1000, Abcam, #ab7260, RRID: AB_305808 ), rabbit anti-S100β (1:1000, Abcam, #ab52642, RRID: AB_882426 ), rabbit anti-Iba1 (1:500, Fujifilm Wako Pure Chemical Industries, #019–19741, RRID: AB_839504 ), mouse anti-CD31 (1:500, Cell Signaling Technology, #3528, RRID: AB_2160882 ) or rabbit anti-ATF3 (1:200, Sigma-Aldrich, #HPA001562, RRID: AB_1078233 ). .. After washing three times with PBS, the samples were incubated for 3 h at room temperature with appropriate secondary antibodies conjugated with Alexa Fluor 594, 488 and/or 405 (1:200, Thermo Fisher Scientific).

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    Blocking Assay:

    Article Title: Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.
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    Alomone Labs guinea pig anti-trpv1 antibody
    <t>TRPV1-mediated</t> nociceptive sensitization in the DRG and spinal cord dorsal horn (SC) following CCI and treatment. (A) Schematic illustration of the proposed mechanism: Injury-induced <t>TRPV1</t> ion channel activation triggers calcium influx and downstream CGRP release, which activates adenylate cyclase/PKA signaling to amplify neuropathic pain sensitization. (B) Representative immunofluorescence images of the DRG stained for TRPV1 (red), NeuN (green), and DAPI (blue). The Injury group shows marked up-regulation of TRPV1 in sensory neurons. Dex/Lid@PLX/HA treatment substantially reduces TRPV1 expression, restoring it to near-Naive levels. Scale bars, 200 μm (overview) and 50 μm (inset). (C) Immunofluorescence staining for TRPV1 (red) and NeuN (green) in the spinal dorsal horn. The dashed line indicates the dorsal horn boundary. Dex/Lid@PLX/HA significantly suppresses injury-induced central TRPV1 up-regulation. Scale bar, 200 μm. (D to F) Quantitative analysis of the relative TRPV1 + area in the DRG (top) and spinal cord (middle), and the SGC/neuron ratio. Dex/Lid@PLX/HA shows marked suppression of TRPV1 overexpression relative to the injury group. Data are presented as mean ± SEM. **** P < 0.0001, ** P < 0.01, * P < 0.05, ns: not significant.
    Guinea Pig Anti Trpv1 Antibody, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    guinea pig antitransient receptor potential vanilloid 1  (Alomone Labs)
    93
    Alomone Labs guinea pig antitransient receptor potential vanilloid 1
    <t>TRPV1-mediated</t> nociceptive sensitization in the DRG and spinal cord dorsal horn (SC) following CCI and treatment. (A) Schematic illustration of the proposed mechanism: Injury-induced <t>TRPV1</t> ion channel activation triggers calcium influx and downstream CGRP release, which activates adenylate cyclase/PKA signaling to amplify neuropathic pain sensitization. (B) Representative immunofluorescence images of the DRG stained for TRPV1 (red), NeuN (green), and DAPI (blue). The Injury group shows marked up-regulation of TRPV1 in sensory neurons. Dex/Lid@PLX/HA treatment substantially reduces TRPV1 expression, restoring it to near-Naive levels. Scale bars, 200 μm (overview) and 50 μm (inset). (C) Immunofluorescence staining for TRPV1 (red) and NeuN (green) in the spinal dorsal horn. The dashed line indicates the dorsal horn boundary. Dex/Lid@PLX/HA significantly suppresses injury-induced central TRPV1 up-regulation. Scale bar, 200 μm. (D to F) Quantitative analysis of the relative TRPV1 + area in the DRG (top) and spinal cord (middle), and the SGC/neuron ratio. Dex/Lid@PLX/HA shows marked suppression of TRPV1 overexpression relative to the injury group. Data are presented as mean ± SEM. **** P < 0.0001, ** P < 0.01, * P < 0.05, ns: not significant.
    Guinea Pig Antitransient Receptor Potential Vanilloid 1, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    guinea pig igg anti trpv1  (Neuromics)
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    Neuromics guinea pig igg anti trpv1
    ( A ) Overview of the targeting strategy for the construction of Cpne6 −/− knockout mice. ( B ) Genotyping results showing Cpne6 +/− , Cpne6 − /− and Cpne6 +/+ gene products. ( C ) Representative western blot analysis for Copine-6 expression in the DRG of Cpne6 +/+ and Cpne6 −/− mice. ( D ) Schematic representation of local DRG-rescue by injection of the AAV9-hSyn-Copine-6-EGFP virions into the DRG of Cpne6 −/− mice. ( E ) Confocal micrographs of Copine-6 immunofluorescence (red) and EGFP fluorescence (green) from the DRGs of Cpne6 −/− mice DRG-injected with either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions (1 × 10 13 viral genomes/mL; 2 μL). Scale bars are 100 μm. ( F – I ) Results of the behavioral tests performed on of Cpne6 +/+ and Cpne6 −/− mice DRG injected with either AAV9-hSyn-mCopine-6-EGFP virions or AAV9-hSyn-EGFP control virions. Tests are as follows: von Frey ( F ), Hargreaves ( G ), hot plate ( H ) and dry ice ( I ). n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. *Indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group. G, *** P = 0.0007; #### P < 0.0001. H, 50 °C, ** P = 0.0062, ## P = 0.0021; 52 °C, * P = 0.0292, # P = 0.0164; 55 °C, ** P = 0.006, # P = 0.0232 (one-way ANOVA followed by Bonferroni multiple comparisons test). ( J , K ) On the 35 th day after viral injection of either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions mice were injected with 25 μL of CFA into the plantar surface of right hindpaw and Hargreaves ( J ) or von Frey ( K ) tests were performed at time intervals indicated; n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. * indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group at time points indicated. J, 0 d, ** P = 0.0029, ### P = 0.0001; 1 d, * P = 0.0372, ## P = 0.0029 ; 3 d, * P = 0.0252, # P = 0.0113; 5 d, ** P = 0.009, ## P = 0.0045 . Two-way ANOVA with Bonferroni multiple comparisons test. .
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    Image Search Results


    TRPV1-mediated nociceptive sensitization in the DRG and spinal cord dorsal horn (SC) following CCI and treatment. (A) Schematic illustration of the proposed mechanism: Injury-induced TRPV1 ion channel activation triggers calcium influx and downstream CGRP release, which activates adenylate cyclase/PKA signaling to amplify neuropathic pain sensitization. (B) Representative immunofluorescence images of the DRG stained for TRPV1 (red), NeuN (green), and DAPI (blue). The Injury group shows marked up-regulation of TRPV1 in sensory neurons. Dex/Lid@PLX/HA treatment substantially reduces TRPV1 expression, restoring it to near-Naive levels. Scale bars, 200 μm (overview) and 50 μm (inset). (C) Immunofluorescence staining for TRPV1 (red) and NeuN (green) in the spinal dorsal horn. The dashed line indicates the dorsal horn boundary. Dex/Lid@PLX/HA significantly suppresses injury-induced central TRPV1 up-regulation. Scale bar, 200 μm. (D to F) Quantitative analysis of the relative TRPV1 + area in the DRG (top) and spinal cord (middle), and the SGC/neuron ratio. Dex/Lid@PLX/HA shows marked suppression of TRPV1 overexpression relative to the injury group. Data are presented as mean ± SEM. **** P < 0.0001, ** P < 0.01, * P < 0.05, ns: not significant.

    Journal: Biomaterials Research

    Article Title: Injectable Poloxamer and Hyaluronic Acid Hydrogel for Sustained Co-Delivery of Dexamethasone and Lidocaine Ameliorates Neuropathic Pain

    doi: 10.34133/bmr.0373

    Figure Lengend Snippet: TRPV1-mediated nociceptive sensitization in the DRG and spinal cord dorsal horn (SC) following CCI and treatment. (A) Schematic illustration of the proposed mechanism: Injury-induced TRPV1 ion channel activation triggers calcium influx and downstream CGRP release, which activates adenylate cyclase/PKA signaling to amplify neuropathic pain sensitization. (B) Representative immunofluorescence images of the DRG stained for TRPV1 (red), NeuN (green), and DAPI (blue). The Injury group shows marked up-regulation of TRPV1 in sensory neurons. Dex/Lid@PLX/HA treatment substantially reduces TRPV1 expression, restoring it to near-Naive levels. Scale bars, 200 μm (overview) and 50 μm (inset). (C) Immunofluorescence staining for TRPV1 (red) and NeuN (green) in the spinal dorsal horn. The dashed line indicates the dorsal horn boundary. Dex/Lid@PLX/HA significantly suppresses injury-induced central TRPV1 up-regulation. Scale bar, 200 μm. (D to F) Quantitative analysis of the relative TRPV1 + area in the DRG (top) and spinal cord (middle), and the SGC/neuron ratio. Dex/Lid@PLX/HA shows marked suppression of TRPV1 overexpression relative to the injury group. Data are presented as mean ± SEM. **** P < 0.0001, ** P < 0.01, * P < 0.05, ns: not significant.

    Article Snippet: The sections were then incubated overnight at 4 °C with the following primary antibodies: TRPV1 (Alomone Labs, catalog number ACC-030-GP), Iba-1 (Abcam, catalog number ab5076), NeuN (Abcam, catalog number ab104224), CD68 (Abcam, catalog number ab31630), CD163 (Abcam, catalog number ab182422), CGRP (Abcam, catalog number ab47027), GFAP (Millipore, catalog number MAB360), and NF200 (Abcam, catalog number ab8135).

    Techniques: Activation Assay, Immunofluorescence, Staining, Expressing, Over Expression

    ( A ) Overview of the targeting strategy for the construction of Cpne6 −/− knockout mice. ( B ) Genotyping results showing Cpne6 +/− , Cpne6 − /− and Cpne6 +/+ gene products. ( C ) Representative western blot analysis for Copine-6 expression in the DRG of Cpne6 +/+ and Cpne6 −/− mice. ( D ) Schematic representation of local DRG-rescue by injection of the AAV9-hSyn-Copine-6-EGFP virions into the DRG of Cpne6 −/− mice. ( E ) Confocal micrographs of Copine-6 immunofluorescence (red) and EGFP fluorescence (green) from the DRGs of Cpne6 −/− mice DRG-injected with either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions (1 × 10 13 viral genomes/mL; 2 μL). Scale bars are 100 μm. ( F – I ) Results of the behavioral tests performed on of Cpne6 +/+ and Cpne6 −/− mice DRG injected with either AAV9-hSyn-mCopine-6-EGFP virions or AAV9-hSyn-EGFP control virions. Tests are as follows: von Frey ( F ), Hargreaves ( G ), hot plate ( H ) and dry ice ( I ). n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. *Indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group. G, *** P = 0.0007; #### P < 0.0001. H, 50 °C, ** P = 0.0062, ## P = 0.0021; 52 °C, * P = 0.0292, # P = 0.0164; 55 °C, ** P = 0.006, # P = 0.0232 (one-way ANOVA followed by Bonferroni multiple comparisons test). ( J , K ) On the 35 th day after viral injection of either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions mice were injected with 25 μL of CFA into the plantar surface of right hindpaw and Hargreaves ( J ) or von Frey ( K ) tests were performed at time intervals indicated; n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. * indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group at time points indicated. J, 0 d, ** P = 0.0029, ### P = 0.0001; 1 d, * P = 0.0372, ## P = 0.0029 ; 3 d, * P = 0.0252, # P = 0.0113; 5 d, ** P = 0.009, ## P = 0.0045 . Two-way ANOVA with Bonferroni multiple comparisons test. .

    Journal: The EMBO Journal

    Article Title: Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat

    doi: 10.1038/s44318-025-00487-0

    Figure Lengend Snippet: ( A ) Overview of the targeting strategy for the construction of Cpne6 −/− knockout mice. ( B ) Genotyping results showing Cpne6 +/− , Cpne6 − /− and Cpne6 +/+ gene products. ( C ) Representative western blot analysis for Copine-6 expression in the DRG of Cpne6 +/+ and Cpne6 −/− mice. ( D ) Schematic representation of local DRG-rescue by injection of the AAV9-hSyn-Copine-6-EGFP virions into the DRG of Cpne6 −/− mice. ( E ) Confocal micrographs of Copine-6 immunofluorescence (red) and EGFP fluorescence (green) from the DRGs of Cpne6 −/− mice DRG-injected with either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions (1 × 10 13 viral genomes/mL; 2 μL). Scale bars are 100 μm. ( F – I ) Results of the behavioral tests performed on of Cpne6 +/+ and Cpne6 −/− mice DRG injected with either AAV9-hSyn-mCopine-6-EGFP virions or AAV9-hSyn-EGFP control virions. Tests are as follows: von Frey ( F ), Hargreaves ( G ), hot plate ( H ) and dry ice ( I ). n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. *Indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group. G, *** P = 0.0007; #### P < 0.0001. H, 50 °C, ** P = 0.0062, ## P = 0.0021; 52 °C, * P = 0.0292, # P = 0.0164; 55 °C, ** P = 0.006, # P = 0.0232 (one-way ANOVA followed by Bonferroni multiple comparisons test). ( J , K ) On the 35 th day after viral injection of either AAV9-hSyn-Copine-6-EGFP virions or AAV9-hSyn-EGFP control virions mice were injected with 25 μL of CFA into the plantar surface of right hindpaw and Hargreaves ( J ) or von Frey ( K ) tests were performed at time intervals indicated; n = 8 mice in Cpne6 +/+ group, n = 6 mice in both Cpne6 −/− groups. Data are shown as mean ± SEM. * indicate difference from Cpne6 +/+ group and # indicate difference from Cpne6 −/− + hSyn-Copine-6 group at time points indicated. J, 0 d, ** P = 0.0029, ### P = 0.0001; 1 d, * P = 0.0372, ## P = 0.0029 ; 3 d, * P = 0.0252, # P = 0.0113; 5 d, ** P = 0.009, ## P = 0.0045 . Two-way ANOVA with Bonferroni multiple comparisons test. .

    Article Snippet: Guinea Pig IgG anti-TRPV1 (IF 1:300) , Neuromics , Cat# GP14100 RRID: AB_1624142.

    Techniques: Knock-Out, Western Blot, Expressing, Injection, Immunofluorescence, Fluorescence, Control